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desvenlafaxine will boost the degree or influence of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep an eye on. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, four hundred mg) minimize the CYP2D6 substrate dose by as much as 50%; no dosage adjustment required with desvenlafaxine doses seven consecutive

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